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Retroviruses are fiendish things, even more devious and persistent than the average virus. They take their name from the capacity to move backward against the usual expectations of how a creature translates its genes into working proteins. Instead of using RNA as a template for translating into DNA into protein—the usual route by which genetic information becomes living reality—a retrovirus converts its RNA into DNA within a host cell; its viral DNA then penetrates the cell nucleus and gets itself integrated into the genome of the host cell, thereby guaranteeing replication of the virus whenever the host cell reproduces. (en) |
