|
so:text
|
work... looked at the fact that shortening was being looked at by two different groups... by people interested in counteracting the aging process, and... in exactly the opposite fashion, by people who were interested in tumorigenesis in cancer. ...Tumors ...always had active, that's the enzyme that lengthens our telomeres. So those folks were interested in bringing about a halt in the lengthening of telomeres... to counteract cancer, and the folks that were studying the process were interested in lengthening telomeres... to generate greater repair capacity. ...y point was evolutionarily speaking this looks like a pleiotropic effect, that the genes which create the tendency of the cells to be limited in their capacity to replace themselves, are providing a benefit in youth... that we are largely free of tumors and cancer at the inevitable late life cost that we grow feeble and inefficient, and eventually die. ...hat matches a very old hypothesis in evolutionary theory by somebody I was fortunate enough to know, George Williams... (en) |
